Abstract: In healthcare applications, there is a growing need to develop machine learning models that use data from a single source, such as that from a wrist wearable device, to monitor physical activities, assess health risks, and provide immediate health recommendations or interventions. However, the limitation of using single-source data often compromises the model's accuracy, as it fails to capture the full scope of human activities. While a more comprehensive dataset can be gathered in a lab setting using multiple sensors attached to various body parts, this approach is not practical for everyday use due to the impracticality of wearing multiple sensors. To address this challenge, we introduce a transfer learning framework that optimizes machine learning models for everyday applications by leveraging multi-source data collected in a laboratory setting. We introduce a novel metric to leverage the inherent relationship between these multiple data sources, as they are all paired to capture aspects of the same physical activity. Through numerical experiments, our framework outperforms existing methods in classification accuracy and robustness to noise, offering a promising avenue for the enhancement of daily activity monitoring.